The edifice was built in 1900 according to the designs of an unknown architect, and was opened as the Serbian Pasteur Institute, one of the first health care institutions for preventive medicine in the Balkans.

The original layout of this ground-level building had the form of the Cyrillic letter p (П), with a central hall connected to two examination rooms and one laboratory on each side. After 1923, it changed its function and from the old Pasteur’s Institute, which was a military establishment, becomes an Epidemiological Institute, and later the Hygiene Institute, reverting to a civil function. Through the addition of the lateral wings, its horizontal silhouette changed, but the symmetry and style were preserved.  

This beautiful building is academically composed, with a symmetrical structure of volumes, but in the spirit of the eclectic trends of the time, with decorative renaissance elements on the façade.

The conservation and restoration works to the building were completed in 1984. They were executed according to the designs of the architect Milorad Vojinović, following which the building obtained a new function. It now houses the Museum of Health, the branch of the Serbian Physicians Society and the School of Health Education.